*Correspondence: Yi Li, liyilebmed@henu.edu.cn, These authors have contributed equally to this work, Advancing the Understanding of Emergence of SARS-CoV-2 Genetic Variants and COVID-19 Vaccine Efficacy: Essential Clinical and Molecular Insights and Breakthroughs, View all The study complied with the principles of the Declaration of Helsinki and Good Clinical Practice, and was approved by the Ethics Committee of Henan Provincial Peoples Hospital (approval number 20210051, date of approval May 24, 2021). Shaw AT, Bauer TM, de Marinis F, Felip E, Goto Y, Liu G, et al. Eur J Med Res. The results were notable: Adjusting for demographics and co-morbidities, the risk for a COVID-19 diagnosis was 12 percent lower for people with type O blood and the risk for severe COVID-19 or death was 13 percent lower, compared to those with A, AB, or B blood types. Socio-economic status is a big vulnerability, and age and health are next in line for susceptibility. In this study, the older population produced lower levels of neutralizing antibodies, IFN-, B-lymphocytes, and IL-6, similar to that in previous studies (3, 25). After the administration of the inactivated vaccine, the GMC of neutralizing antibodies decreased from 50.2 IU/mL on day 30 to 17.7 IU/mL (average decrease: 32.3%) and 13.3 IU/mL (average decrease: 25.9%) on days 180 and 240, respectively, representing an average monthly decrease of 10.1% (Figure2B). We are committed to bringing you researched, expert-driven content to help you make more informed decisions Case Rep Infect Dis. doi:10.1128/spectrum.01181-21, 21. (19, 20), we divided participants into three BMI groups: <18.5, 18.523.9, and >23.9 kg/cm2. The concentration kinetics of IgG neutralizing antibodies were evaluated against the RBD for all study participants at least once during the 8-month timeframe and at least four times for 119 participants (20%). Neurological side effects occur with any of the approved vaccines but VST particularly occurs after vaccination with vector-based vaccines. However, in China, data on long-term immunogenicity and adverse effects of inactivated vaccines produced by different manufacturers or the same manufacturer have not been reported. Opens in a new tab or window, Share on LinkedIn. 2021;8(2021):3619131. doi:10.1155/2021/3619131 Progress and challenge of COVID-19 vaccine development. Co-authors disclosed support from Dell Loy Hansen Heart Foundation Heart Institute, Intermountain Research and Medical Foundation, AstraZeneca, PCORnet, GlaxoSmithKline, CareCentra, and LabMe.ai, as well as licensing of intellectual property from Alluceo and CareCentra. Safety and immunogenicity of heterologous boost immunisation with an orally administered aerosolised Ad5-nCoV after two-dose priming with an inactivated SARS-CoV-2 vaccine in Chinese adults: A randomised, open-label, single-centre trial. Acta Neurol Scand. Nausea. Vaccine (2022) 40:218490. If a patient was O-negative, they were particularly protected from the novel coronavirus, the authors noted. World J Clin Cases. Epub 2021 May 25. There was no association with blood type and either susceptibility to COVID-19 infection or disease severity in a large cohort study, researchers said. Acute disseminated encephalomyelitis following the COVID-19 vaccine Ad26.COV2.S, a case report. In fact, one might say that people on . 20052022 MedPage Today, LLC, a Ziff Davis company. Table2 Factors associated with the neutralization antibody concentration after the administration of the Chinese inactivated COVID-19 vaccine. The early response observed 30 days after the second dose showed a boost effect linked to the same manufacturers scheme. The Public Health Agency of Canada, Health Canada, and provincial and territorial health authorities continue to: This can progress to affect the rest of the body and cause. The mixed model distribution curves of log2-transformed neutralizing antibodies and log10-transformed cellular response with duration adjusted by age, sex, BMI, occupation, vaccination mode, duration since the second dose, interval between doses of vaccination, and ABO blood type were plotted using Prism 8.0 (GraphPad Software Inc., USA). 2022 Aug 15;369:577901. doi: 10.1016/j.jneuroim.2022.577901. But the virus is still in your system and you can still pass it to someone else.". Wang L, Fan JP, Xu Y, Wang JL, Wang MZ. And guess what: People with Type A blood have higher levels of VWF naturally than people with type O blood, Dr. Udden points out. First-line lorlatinib or crizotinib in advanced ALK-positive lung cancer. Please enable it to take advantage of the complete set of features! But VWF also encourages clotting. Data are presented as mean (95% confidence interval [CI]) from the linear mixed-effects model adjusted for vaccine manufacturer, sex, blood type, age, occupation, and BMI. The blood group types did not affect the clinical outcomes. Participants with blood type A had lower levels of neutralizing antibodies than those with blood type B during 114 days after vaccination (least-square mean difference = 15.8, 95% CI 11.025.2; p = 0.044) (Table S2). 1:38 Syncope following injection 2:36 Primarily headaches 3:37 Clotting disorder after vaccination 4:37 Any neurological events 4:50 Dexamethasone and surgical site infection 5:51 Also had people. -, Wiedmann M, Skattr T, StrayPedersen A, et al. Methods: This prospective, multicenter, observational, longitudinal study involved 595 participants with a negative SARS-CoV-2 polymerase chain reaction result who were serologically tested and followed for 8 months after vaccination. Our product picks are editor-tested, expert-approved. Safety definitions and a list of solicited adverse events were defined as previously described (16, 17). Patients' mean age was 42, 77% were women, and most were white. Congestion/runny nose. If these side effects occur, they should go away in a few days. doi:10.1038/s41422-021-00590-x, 23. Federal government websites often end in .gov or .mil. Copyright 2023 Yuan, Xu, Ma, Chen, Wang, Wang, Jing, Zhang, Wang, Yan, Zhang, Zhao and Li. J Clin Epidemiol (2022) 144:16372. The https:// ensures that you are connecting to the Conversely, participants aged >50 years had higher levels of reactive IL-6 than those aged 1830 years (B = 1.0, 95% CI 0.61.5; p < 0.001) (Table6; Figure3E). doi:10.1001/jama.2021.19499, 11. Lau YL, Fan Leung T, Sirvan Cetin B, Cagri Dinleyici E, Huang LM, Halperin SA, et al. On the other hand, the frequency of blood group O was significantly lower in the COVID-19 patients, compared to the control group . The retailer's cutting-edge new offering is angering some local residents. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Most participants rapidly developed neutralizing antibodies after two doses of the Chinese COVID-19 inactivated vaccine administered 3 weeks apart. doi:10.1016/S0140-6736(22)00094-0, 7. if( navigator.sendBeacon ) { But VWF also . To control the COVID-19 epidemic and build an active immunization barrier among populations, the Chinese Government provided free COVID-19 vaccination to all citizens as of December 2020 (3). Lancet (2022) 399:5219. Table6 Factors associated with IL-6 level after the administration of the Chinese COVID-19 inactivated vaccine. The virus can lead to pneumonia, respiratory failure, heart problems, liver problems, septic shock, and death. O is the most common blood type in the U.S.: 37 percent of white Americans fall into this category, according to the American Red Cross, with the numbers rising to 47 percent among African-Americans, 53 percent among Latinx-Americans, and 39 percent of Asian-Americans. Neutralizing antibody levels usually increase after the second administration of mixed vaccines (22, 23). 14:1107866. doi: 10.3389/fimmu.2023.1107866. Disclaimer. Accessibility The most basic idea is that blood type might influence a persons ability to fight the virus, says David Aronoff, M.D., director of the division of infectious diseases at Vanderbilt University Medical Center in Nashville. This article is part of Harvard Medical School's continuing coverage of medicine, biomedical research, medical education and policy related to the SARS-CoV-2 pandemic and the disease COVID-19. Nat Commun (2021) 12:1162. doi:10.1038/s41467-021-21444-5, 22. Because these detected records included missing data for neutralizing antibodies and cellular immune responses, we used mixed linear models that can handle unequal numbers of repeated observations for individuals when there were random missing data. The most commonly reported side effects were: Fever Headache Fatigue (tiredness) Pain at the injection site Helpful tips to relieve side effects Adults To relieve pain or swelling on the arm where you got the shot: Apply a clean, cool, wet washcloth over the area. Side effects can be a powerful deterrent stopping people from getting vaccinated. Therefore, the objective of this study was to evaluate the cellular immune responses and neutralizing antibody kinetics of homologous and heterologous administrations of an inactivated coronavirus disease 2019 (COVID-19) vaccine 240 days . This site needs JavaScript to work properly. "Given the large and prospective nature of our study and its strongly null results, we believe that important associations of SARS-CoV-2 and COVID-19 with ABO groups are unlikely and will not be useful factors associated with disease susceptibility or severity on either an individual or population level for similar environments and ancestries," they concluded. Even DNA testing company 23andMe tapped their customers and found that among 750,000 people who were diagnosed and hospitalized for Covid (this was prior to vaccines), those with type O were more protected. In fact, most people dont even know whether theyre Type A, B, AB, or O. But recently, the genetics company 23andMe revealed preliminary data from their own study showing that a person's blood type, which is determined by the ABO gene, appears to affect susceptibility to coronavirus. The following outcomes were selected and defined by the authors based on information from regulatory authorities, previous studies, large-scale adverse events initiatives: febrile seizure, aseptic. Women had 6.5 IU more neutralizing antibodies than men (B = 0.7, 95% CI 0.111.28; p = 0.021; least-square mean difference = 6.5, 95% CI 5.110.1, p = 0.019) 240 days after vaccination (Table S1). Antigen-specific humoral immune responses were detected using a commercial enzyme-linked immunosorbent assay (ELISA) anti-SARS-CoV-2 S kit (Shanghai GeneoDx Biotech, Ltd., Co., Shanghai, China), which detects neutralizing immunoglobulin G (IgG) antibodies against the SARS-CoV-2 spike protein receptor-binding domain (RBD) on a universal microplate reader (DNM-9602; Beijing Pulang Ltd., Co., Beijing, China); values > 6.5 IU/mL were considered positive. The new study's co-author, Joel Ray, MD, of St. Michael's Hospital, suggested that people with these more resistant blood types may have already developed antibodies that can recognize certain aspects of the novel coronavirus and are therefore better prepared to fight it off. In contrast, people with blood type O appear to have about a 50 percent reduced risk of severe COVID-19. But theres another interesting layer to a potential protective element in Type O blood: something called von Willebrand factor, which is a glycoprotein in charge of repairing damage to blood vessels by prompting your blood to clot. We know the Covid virus damages the lining of your blood vessels. Your body then releases von Willebrand factor, or VWF, into your blood so it can fix the damage to the vessel walls. Published by John Wiley & Sons Ltd. Medpage Today is among the federally registered trademarks of MedPage Today, LLC and may not be used by third parties without explicit permission. Treatment of these side effects is not at variance from similar conditions due to other causes. Si vous ne souhaitez pas que nos partenaires et nousmmes utilisions des cookies et vos donnes personnelles pour ces motifs supplmentaires, cliquez sur Refuser tout. The number of participants was relatively small, and at the time of the clinical study design, the administrators did not advocate the administration of vaccines from different manufacturers for separate doses. Lorsque vous utilisez nos sites et applications, nous utilisons des, authentifier les utilisateurs, appliquer des mesures de scurit, empcher les spams et les abus; et. And for more on the latest COVID-19 news, find out How Likely You Are to Catch COVID in the Next Month, Expert Says. 2023 Feb 25;28(1):102. doi: 10.1186/s40001-023-00992-0. Lustig Y, Sapir E, Regev-Yochay G, Cohen C, Fluss R, Olmer L, et al. Previous research has found that people with A blood types are more at risk. Some people with COVID-19 develop abnormal blood clots, including in the smallest blood vessels. Share on Facebook. All participants provided their informed consent in writing before enrollment. Vaccination is the most effective measure to reduce mortality from COVID-19 and serious diseases (12); however, vaccines are scarce in certain countries and some regions in China (13). The inactivated vaccine was administered as a single intramuscular injection for each of the two approved doses. The Centers for Disease Control and Prevention on Friday published new data listing the most common side effects Americans reported after receiving shots of Pfizer 's or Moderna 's Covid-19 vaccines.
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